Occupational injuries among construction workers at the Chep Lap Kok Airport construction site, Hong Kong : analysis of accident rates, and the association between injuries, error types and their contributing factors : a thesis presented in partial fulfilment of the requirements for the degree of Master of Aviation at Massey University, Palmerston North, New Zealand

Accidents on construction sites are a major cause of morbidity and mortality in Hong Kong. This study investigated the likely causes of occupational injuries that were present among the construction workers during the construction of the new Chep Lap Kok (CLK) Airport in Hong Kong. In order to accumulate the requisite information, 1648 accident investigation reports in a four-year period (1993-1996) were reviewed. The first part of the study described the pattern and magnitude of occupational injuries among the CLK construction workers and compared the accident rates of the CLK workers with those of the construction industry as a whole in Hong Kong. The study examined the effects of the workplace infrastructure at CLK in order to explain why this site presented fewer work place injuries and accidents than other workplaces. The second part of the research used these injury and accident occurrences as the basis to construct the causes of accidents and injuries within an error causation classification system. The results showed that at CLK, the commonest workplace injury was contusion & crushing which appeared to be due to mistakes made through lapses in memory often caused by pressure of work being imposed on the employee. This section also indicated what types of errors were most closely associated with what kinds of injuries and what conditions were most likely to trigger these types of events. Among the major associations were links between contusion and crushing and violation error, perceptual error; between memory lapse and work pressure, equipment deficiencies, poor working environment, fatigue, and between violation error and work pressure. The research suggested that work pressure was an important contributing factor to construction injury and it increased the prevalence of a human error type namely, memory lapse many fold. The outcomes from this study provide important new information on the causes and types of errors which have led to occupational injuries among construction workers in Hong Kong. A better understanding of the human factors-based causes of accidents and injuries in the construction industry and an inculcation of a safety culture on construction sites are critically important in the reduction of the rate of construction accidents and improvement of workers' human performance. The results should assist the construction industry in the designing accident prevention training and education strategies, estimating human error probabilities, and the monitoring organizational safety performance

Genome-wide association study identifies FCGR2A as a susceptibility locus for Kawasaki disease

Kawasaki disease is a systemic vasculitis of unknown etiology, with clinical observations suggesting a substantial genetic contribution to disease susceptibility. We conducted a genome-wide association study and replication analysis in 2,173 individuals with Kawasaki disease and 9,383 controls from five independent sample collections. Two loci exceeded the formal threshold for genome-wide significance. The first locus is a functional polymorphism in the IgG receptor gene FCGR2A (encoding an H131R substitution) (rs1801274; P = 7.35 × 10 -11, odds ratio (OR) = 1.32), with the A allele (coding for histadine) conferring elevated disease risk. The second locus is at 19q13, (P = 2.51 × 10 -9, OR = 1.42 for the rs2233152 SNP near MIA and RAB4B; P = 1.68 × 10 -12, OR = 1.52 for rs28493229 in ITPKC), which confirms previous findings. The involvement of the FCGR2A locus may have implications for understanding immune activation in Kawasaki disease pathogenesis and the mechanism of response to intravenous immunoglobulin, the only proven therapy for this disease.</p